LIVE 32 submissions / 186 comments / 1548 upvotes▲72 Show BN: A $180 open-source thermocycler that hits 3 °C/s ramp rates▲63 Base editor corrects a point mutation in adult mouse liver with no detectable off-targets▲53 Ask BN: How do you validate a community lab BSL-1 setup without an institution behind you?▲49 A cell-free protein synthesis kit you can freeze-dry at home▲47 The reproducibility crisis is a metadata crisis▲44 Show BN: I sequenced my sourdough starter and built a strain tracker for it// The revolution will not be peer reviewed.LIVE 32 submissions / 186 comments / 1548 upvotes▲72 Show BN: A $180 open-source thermocycler that hits 3 °C/s ramp rates▲63 Base editor corrects a point mutation in adult mouse liver with no detectable off-targets▲53 Ask BN: How do you validate a community lab BSL-1 setup without an institution behind you?▲49 A cell-free protein synthesis kit you can freeze-dry at home▲47 The reproducibility crisis is a metadata crisis▲44 Show BN: I sequenced my sourdough starter and built a strain tracker for it// The revolution will not be peer reviewed.

Bioinformatics / AI

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1. ▲ The reproducibility crisis is a metadata crisis (nature.com) Bioinformatics / AI 47 points | open_assay | 17 hours ago | 6 comments
2. ▲ A public benchmark for protein design models that actually gets wet-lab validated (biorxiv.org) Bioinformatics / AI 36 points | crispr_kid | 1 day ago | 6 comments
3. ▲ Structural prediction is solved. Function is not. (example-structural-bio.org) Bioinformatics / AI 24 points | crispr_kid | 2 days ago | 6 comments
4. ▲ Show BN: A lab notebook that is just plain text files and a Makefile (github.com) Show BN Bioinformatics / AI 20 points | open_assay | 2 days ago | 6 comments